Serving Australia and NZ
1300 543 373
Return to Previous Page

2’2’-cGAMP, 500 µg

2’2’-cGAMP, 500 µg

Quick Overview:

Product Code: tlrl-nacga22
Supplier: InvivoGen

  • Details

    STING ligand. 2’2’-cGAMP, cyclic [G(2’,5’)pA(2’,5’)p], is a synthetic cyclic di-nucleotide that binds STING (stimulator of IFN genes) and subsequently induces TBK1-IRF3-dependent production of IFN-β [1]. 2’2’-cGAMP is the isomer of cGAMP most similar to 2’3’-cGAMP in terms of STING binding and type I interferon induction [1]. Certain variants of STING are able to distinguish between noncanonical and canonical cGAMP [2]. cGAMP is more potent in activating type I IFN than c-di-IMP, c-di-AMP and c-diGMP, other cyclic dinucleotides that also bind STING [3]. References: 1. Zhang X. et al., 2013. Cyclic GMP-AMP containing mixed phosphdiester linkages is an endogenous high-affinity ligand for STING. Mol Cell.51(2):226-35. 2. Diner E. et al., 2013. The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING. Cell Rep. 3(5):1355-61. 3. Burdette D. et al., 2011. STING is a direct innate immune sensor of cyclic di-GMP. Nature. 478(7370):515-8.
  • Additional Information

    Supplier name InvivoGen
    Product Type Reagents
    Size 500 microg
    Aliases Cyclic [G(2’,5’)pA(2’,5’)p], cyclic GMP-AMP, c-GpAp sodium salt
    Publications Publication List
    Datasheet URL View Datasheet
    Categories Reagents,PRR ligands
  • Images