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2’3’-cGAMP, 1 mg

2’3’-cGAMP, 1 mg

Quick Overview:

Product Code: tlrl-nacga23-1
Supplier: InvivoGen

  • Details

    STING ligand. 2’3’-cGAMP (cyclic [G(2’,5’)pA(3’,5’)p]) is produced in mammalian cells by cGAS (cGAMP synthase) in response to double-stranded DNA in the cytoplasm. 2’3’-cGAMP is also referred to as “noncanonical“ cGAMP due to the presence of the atypical 2’-5’ phosphodiester linkage between the guanosine and the adenosine. Similar to the canonical 3’3’-cGAMP, 2’3’-cGAMP serves as a second messenger to activate innate immune responses by binding to STING (stimulator of IFN genes) and subsequently inducing the TBK1-IRF3-dependent production of IFN-β [1]. Structural and functional studies revealed that noncanonical 2’3’-cGAMP is distinct from the canonical 3’3’-cGAMP produced by bacteria [2,3]. 2'3'-cGAMP binds to STING with a much greater affinity than 3'3'-cGAMP [1]. Certain variants of STING are able to distinguish between noncanonical and canonical cGAMP [2]. References 1. Zhang X. et al., 2013. Cyclic GMP-AMP containing mixed phosphdiester linkages is an endogenous high-affinity ligand for STING. Mol Cell.51(2):226-35. 2. Diner E. et al., 2013. The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING. Cell Rep. 3(5):1355-61. 3. Gao P. et al., 2013. Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell. 153(5):1094-107.
  • Additional Information

    Supplier name InvivoGen
    Product Type Reagents
    Size 1 mg
    Aliases Cyclic [G(2’,5’)pA(3’,5’)p], cyclic GMP-AMP, c-GpAp sodium salt
    Publications Publication List
    Datasheet URL View Datasheet
    Categories Reagents,PRR ligands
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