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ABCB4 Antibody, Biotin conjugated

ABCB4 Antibody, Biotin conjugated

Quick Overview:

Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:7957936, PubMed:8898203, PubMed:9366571, PubMed:17523162, PubMed:23468132, PubMed:24806754, PubMed:24723470, PubMed:24594635, PubMed:21820390). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to fu rther enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed:23468132). Required for proper phospholipid bile formation (By similarity). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:24045840). May promote biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:9366571). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (By similarity).

Product Code: CSB-PA001050LD01HU
Supplier: Cusabio

  • Details

    Recombinant Human Phosphatidylcholine translocator ABCB4 protein (530-693AA)
  • Additional Information

    Supplier name Cusabio
    Product Type Antibodies
    Size 100ug
    Group (E.g. Primary) Primary
    Concentration 50ug
    Clonality Polyclonal
    Colour Clear solution
    Target/Antigen ABCB4
    Conjugate Biotin
    Species Reactivity Human
    Host Species Rabbit
    Isotype IgG
    Applications ELISA
    Storage/Storage buffer Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
    Form Liquid
    Purification >95%, Protein G purified
    Aliases Phosphatidylcholine translocator ABCB4 (ATP-binding cassette sub-family B member 4) (Multidrug resistance protein 3) (EC 3.6.3.44) (P-glycoprotein 3), ABCB4, MDR3 PGY3
    Publications Publication List
    Datasheet URL View Datasheet
    Categories Antibodies,Primary Antibodies
  • Images