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ACTL6B Antibody

ACTL6B Antibody

Quick Overview:

Belongs to the chromatin remodeling brain-specific BAF (bBAF) complex, as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth .

Product Code: CSB-PA001237ESR1HU
Supplier: Cusabio

  • Details

    Recombinant Human Actin-like protein 6B protein (1-280AA)
  • Additional Information

    Supplier name Cusabio
    Product Type Antibodies
    Size 100ul
    Group (E.g. Primary) Primary
    Concentration 50ul
    Clonality Polyclonal
    Colour Clear solution
    Target/Antigen ACTL6B
    Conjugate Unconjugated
    Species Reactivity Human
    Host Species Rabbit
    Isotype IgG
    Applications ELISA, IHC
    Storage/Storage buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
    Form Liquid
    Purification Antigen Affinity Purified
    Aliases Actin-like protein 6B (53 kDa BRG1-associated factor B) (Actin-related protein Baf53b) (ArpNalpha) (BRG1-associated factor 53B) (BAF53B), ACTL6B, ACTL6 BAF53B
    Publications Publication List
    Datasheet URL View Datasheet
    Categories Antibodies,Primary Antibodies
  • Images