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A2ML1 Antibody, HRP conjugated

A2ML1 Antibody, HRP conjugated

Quick Overview:

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases.

Product Code: CSB-PA001005LB01HU
Supplier: Cusabio

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases.
Details
Recombinant Human Alpha-2-macroglobulin-like protein 1 protein (625-751AA)
Additional Information
Product Name A2ML1 Antibody, HRP conjugated
Supplier name Cusabio
Group (E.g. Primary) Primary
Concentration 50ug
Clonality Polyclonal
Colour Clear solution
Product Type Antibodies
Conjugate HRP
Size 100ug
Species Reactivity Human
Host Species Rabbit
Applications ELISA
Storage/Storage buffer Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Purification >95%, Protein G purified
Isotype IgG
Aliases Alpha-2-macroglobulin-like protein 1 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9), A2ML1, CPAMD9
Publications Publication List
Target/Antigen A2ML1
Datasheet URL View Datasheet

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