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ASIC1 Antibody

ASIC1 Antibody

Quick Overview:

Isoform 2 and isoform 3 function as proton-gated sodium channels, they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.

Product Code: CSB-PA001142LA01HU
Supplier: Cusabio

  • Details

    Recombinant Human Acid-sensing ion channel 1 protein (195-297AA)
  • Additional Information

    Supplier name Cusabio
    Product Type Antibodies
    Size 100ug
    Group (E.g. Primary) Primary
    Concentration 50ug
    Clonality Polyclonal
    Colour Clear solution
    Target/Antigen ASIC1
    Conjugate Unconjugated
    Species Reactivity Human, Mouse
    Host Species Rabbit
    Isotype IgG
    Applications ELISA, IF, WB
    Storage/Storage buffer Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
    Form Liquid
    Purification >95%, Protein G purified
    Aliases Acid-sensing ion channel 1 (ASIC1) (Amiloride-sensitive cation channel 2, neuronal) (Brain sodium channel 2) (BNaC2), ASIC1, ACCN2 BNAC2
    Publications Publication List
    Datasheet URL View Datasheet
    Categories Antibodies,Primary Antibodies
  • Images