ATF4 is a transcription factor, that accumulates predominantly in osteoblasts, where it regulates terminal osteoblast differentiation and bone formation. As a basic leucine-zipper (bZip) transcription factor, ATF4 can regulate amino acid metabolism, cellular redox state, and anti-stress responses. It also regulates age-related and diet-induced obesity and glucose homeostasis in mammals, and has conserved metabolic functions in flies. Due to its location at chromosome 22q13, a region linked to schizophrenia, ATF4 is considered as a positional candidate gene for schizophrenia. Otherwise, since ATF4 is induced by tumour microenvironmental factors, and regulates processes relevant to cancer progression, it might serve as a potential therapeutic target in cancer. This antibody is a rabbit polyclonal antibody raised against full length human ATF4 antigen.
Recombinant protein of human ATF4
|Product Name||ATF4 Antibody|
|Group (E.g. Primary)||Primary|
|Species Reactivity||Human, Mouse, Rat|
|Applications||ELISA, IHC, WB|
|Storage/Storage buffer||Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Datasheet URL||View Datasheet|