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BAG1 Antibody

BAG1 Antibody

Quick Overview:

Bag1 belongs to the Bcl-2 associated athanogene (BAG) family of multifunctional proteins and was the first of six related proteins isolated from humans. This widely expressed protein interacts with a number of signaling molecules (including Bcl2, HGF receptor and Raf1) as it regulates signaling molecules in pathways involving cell survival, growth and differentiation. The most common role played by Bag1 protein is as an inhibitor of proteins favoring apoptosis. Bag1 also plays a role in Raf1 signaling and binds DNA as a transcription activator. Bag1 protein is a well-characterized inhibitor of its binding partner HSP70. A conserved carboxy-terminal BAG domain within Bag1 interacts with the ATPase domain of HSP70 to negatively regulate heat shock protein chaperone activity. The multiple isoforms of Bag1 protein generated from a single transcript share a common ubiquitin homology domain and a carboxy-terminal Hsp70 binding region but differ in length and cellular localization. The 50 kDa long (Bag1-L) isoform also contains a nuclear localization signal and is often found in the nucleus where it activates transcription. The 46 kDa intermediate (Bag1-M) isoform is found mainly in the cytoplasm but can also translocate to the nucleus when associated with other proteins. The shorter 29-33 kDa isoforms (Bag1-S, Bag-1) isoforms are found primarily in the cytoplasm. High expression of the anti-apoptotic Bag1 protein correlates with increased survival in patients with particular forms of cancer, leading researchers to study possible therapeutic roles for Bag1 protein.

Product Code: CSB-PA002529KA01HU
Supplier: Cusabio

  • Details

    Recombinant protein of human BAG1
  • Additional Information

    Supplier name Cusabio
    Product Type Antibodies
    Size 100ul
    Group (E.g. Primary) Primary
    Concentration 100ul(100ug)
    Clonality Polyclonal
    Colour Clear solution
    Target/Antigen BAG1
    Conjugate Unconjugated
    Species Reactivity Human, Mouse, Rat
    Host Species Rabbit
    Isotype IgG
    Applications ELISA, IHC, WB
    Storage/Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
    Form liquid
    Purification Affinity purification
    Aliases Bag 1;BAG1;BAG1S;HAP;BAG1M;BAG1L specific;RAP46
    Publications Publication List
    Datasheet URL View Datasheet
    Categories Antibodies,Primary Antibodies
  • Images