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BCL2L11 Antibody

BCL2L11 Antibody

Quick Overview:

Bim/Bod is a pro-apoptotic protein belonging to the BH3-only group of Bcl-2 family members including Bad, Bid, Bik, Hrk and Noxa that contain a BH3 domain but lack other conserved BH1 or BH2 domains. Bim induces apoptosis by binding to and antagonizing anti-apoptotic members of the Bcl-2 family. Interactions have been observed with Bcl-2, Bcl-xL, Mcl-1, Bcl-w, Bfl-1 and BHRF-1. Bim functions in regulating apoptosis associated with thymocyte negative selection and following growth factor withdrawal, during which Bim expression is elevated. Three major isoforms of Bim are generated by alternative splicing: BimEL, BimL and BimS. The shortest form, BimS, is the most cytotoxic and is generally only transiently expressed during apoptosis. The BimEL and BimL isoforms may be sequestered to the dynein motor complex through an interaction with the dynein light chain and released from this complex during apoptosis. Apoptotic activity of these longer isoforms may be regulated by phosphorylation. Environmental stress triggers Bim phosphorylation by JNK and results in its dissociation from the dynein complex and increased apoptotic activity.

Product Code: CSB-PA002615KA01HU
Supplier: Cusabio

  • Details

    Recombinant protein of human Bim
  • Additional Information

    Supplier name Cusabio
    Product Type Antibodies
    Size 100ul
    Group (E.g. Primary) Primary
    Concentration 100ul(100ug)
    Clonality Polyclonal
    Colour Clear solution
    Target/Antigen BCL2L11
    Conjugate Unconjugated
    Species Reactivity Human, Mouse, Rat
    Host Species Rabbit
    Isotype IgG
    Applications ELISA, WB
    Storage/Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
    Form liquid
    Purification Affinity purification
    Aliases BAM; BIM; BOD; BimL; BimS; BimEL; BIM-beta6; BIM-beta7; BIM-alpha6;BCL2L11
    Publications Publication List
    Datasheet URL View Datasheet
    Categories Antibodies,Primary Antibodies
  • Images