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BUB1 Antibody

BUB1 Antibody

Quick Overview:

The Mitotic Checkpoint Complex (MCC), which contains Bub1, Bub1b, Bub3, Mad2, and Cdc20, controls chromosome segregation and monitors kinetochore-microtubule interactions. During mitosis, the MCC complex inhibits the ubiquitin ligase activity of the Anaphase Promoting Complex/Cyclosome (APC/C), thereby preventing cells with unaligned chromosomes from prematurely entering anaphase. Research studies have shown that Bub1b and Bub1 kinases are mutated in several types of human malignancies including hematopoietic, colorectal, lung, and breast cancers. Biallelic mutations in Bub1b have been found in mosaic variegated aneuploidy syndrome and premature chromatid separation syndrome. Bub1b mouse germline knockouts are embryonic lethal with heterozygous animals displaying genetic instability, early aging phenotypes, and increased cancer susceptibility. Bub3 binds both Bub1 and Bub1b, facilitating their recruitment to kinetochores, and is required for functional microtubule-kinetochore interactions.

Product Code: CSB-PA002882KA01HU
Supplier: Cusabio

  • Details

    Recombinant protein of human BUB1
  • Additional Information

    Supplier name Cusabio
    Product Type Antibodies
    Size 100ul
    Group (E.g. Primary) Primary
    Concentration 100ul(100ug)
    Clonality Polyclonal
    Colour Clear solution
    Target/Antigen BUB1
    Conjugate Unconjugated
    Species Reactivity Human, Mouse, Rat
    Host Species Rabbit
    Isotype IgG
    Applications ELISA, IHC, WB
    Storage/Storage buffer Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
    Form liquid
    Purification Affinity purification
    Aliases BUB1; BUB1A; BUB1L; hBUB1
    Publications Publication List
    Datasheet URL View Datasheet
    Categories Antibodies,Primary Antibodies
  • Images