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c-di-AMP Control, 1 mg

c-di-AMP Control, 1 mg

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Product Code: tlrl-napapa
Supplier: InvivoGen

  • Details

    STING agonist negative control. c-di-AMP Control, also known as 5'-pApA, is a linear dinucleotide analog that can be obtained after hydrolysis of cyclic diadenylate monophosphate (c-di-AMP) by phosphodiesterases [1]. c-di-AMP is a cyclic dinucleotide (CDN) produced in bacteria in which it functions as a second messenger. CDNs including c-di-AMP bind the cytosolic DNA sensor STING (stimulator of interferon genes) and induce the production of type I interferons (IFNs). Due to its linear conformation, 5'-pApA is intended to serve as a negative control for c-di-AMP in type I IFN induction assays. The importance of dinucleotide conformation has been well established in bacteria, where RNA regulatory riboswitches are able to discriminate between biologically active CDNs and their corresponding linear dinucleotides [2-4]. References: 1. Huynh TN. & Woodward JJ, 2016. Too much of a good thing: regulated depletion of c-di-AMP in the bacterial cytoplasm. Curr Opin Microbiol. 30:22-29. 2. Ren A. et al., 2015. Structural Basis for Molecular Discrimination by a 3',3'-cGAMP Sensing Riboswitch. Cell Rep. 11(1):1-12. 3. Gao J. et al., 2015. Identification and characterization of phosphodiesterases that specifically degrade 3'3'-cyclic GMP-AMP. Cell Res. 25(5):539-50. 4. Witte CE. et al., 2013. Cyclic di-AMP is critical for Listeria monocytogenes growth, cell wall homeostasis, and establishment of infection. MBio. 4(3):e00282-13.
  • Additional Information

    Supplier name InvivoGen
    Product Type Reagents
    Size 1 mg
    Aliases c-di-AMP negative control
    Publications Publication List
    Datasheet URL View Datasheet
    Categories Reagents,PRR ligands
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