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c-di-GMP Control, 1 mg

c-di-GMP Control, 1 mg

Quick Overview:

Product Code: tlrl-napgpg
Supplier: InvivoGen

  • Details

    STING agonist negative control. c-di-GMP Control, also known as 5'-pGpG, is a linear dinucleotide analog that can be obtained after hydrolysis of cyclic diguanylate monophosphate (c-di-GMP) by phosphodiesterases [1]. c-di-GMP is a cyclic dinucleotide (CDN) produced in bacteria in which it functions as a second messenger. c-di-GMP is involved in complex biological processes, such as biofilm formation, virulence and photosynthesis. CDNs including c-di-GMP bind the cytosolic DNA sensor STING (stimulator of interferon genes) and induce the production of type I interferons (IFNs). Due to its linear conformation, 5'-pGpG is intended to serve as a negative control for c-di-GMP in type I IFN induction assays. The importance of dinucleotide conformation has been well established in bacteria, where RNA regulatory riboswitches are able to discriminate between biologically active CDNs and their corresponding linear dinucleotides [2-4]. References: 1. Römling U. et al., 2013. Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger. Microbiol Mol Biol Rev. 77(1): 1–52. 2. Ren A. et al., 2015. Structural Basis for Molecular Discrimination by a 3',3'-cGAMP Sensing Riboswitch. Cell Rep. 11(1):1-12. 3. Gao J. et al., 2015. Identification and characterization of phosphodiesterases that specifically degrade 3'3'-cyclic GMP-AMP. Cell Res. 25(5):539-50. 4. Witte CE. et al., 2013. Cyclic di-AMP is critical for Listeria monocytogenes growth, cell wall homeostasis, and establishment of infection. MBio. 4(3):e00282-13.
  • Additional Information

    Supplier name InvivoGen
    Product Type Reagents
    Size 1 mg
    Aliases c-di-GMP negative control,
    Publications Publication List
    Datasheet URL View Datasheet
    Categories Reagents,PRR ligands
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