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c-di-GMP Fluorinated, 100 µg

c-di-GMP Fluorinated, 100 µg

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Product Code: tlrl-nacdgf
Supplier: InvivoGen

  • Details

    STING Ligand - Difluoro 3'3'-c-di-GMP, cyclic [FdG(3’,5’)pFdG(3’,5’)p]. c-di-GMP Fluorinated (c-di[2’FdGMP]) is a synthetic analog of cyclic diguanylate monophosphate (c-di-GMP) with a fluorine atom at 2’ position of the nucleoside. c-di-GMP is a bacterial second messenger that acts a potent immunostimulant in mammals. It induces production of type I interferons (IFNs) by directly binding to the endoplasmic reticulum-resident receptor STING (stimulator of interferon genes) [1]. The incorporation of fluorine into biologically active molecules is commonly used in medicinal chemistry to improve their metabolic stability or to modulate physicochemical properties such as lipophilicity [2, 3]. Moreover, the introduction of a fluorine atom can change the biological activities of a molecule. Interestingly, when used at low concentrations in various cellular assays, c-di-GMP Fluorinated induces higher levels of type I IFNs than does c-di-GMP. References: 1. Burdette DL. et al., 2011. STING is a direct innate immune sensor of cyclic di-GMP. Nature. 478(7370):515-8. 2. Liu P. et al., 2008. Fluorinated Nucleosides: Synthesis and biological implication. J Fluor Chem. 129(9): 743–766. 3. Böhm HJ. et al., 2004.Fluorine in medicinal chemistry. Chembiochem. 5(5):637-43.
  • Additional Information

    Supplier name InvivoGen
    Product Type Reagents
    Size 100 microg
    Aliases 2’Fluoro-c-di-GMP sodium salt, 2',2''-di-F-c-didGMP, c-di(2’FdGMP)
    Publications Publication List
    Datasheet URL View Datasheet
    Categories Reagents,PRR ligands
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