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c-di-UMP, 1 mg

c-di-UMP, 1 mg

Quick Overview:

Product Code: tlrl-nacdu
Supplier: InvivoGen

  • Details

    STING agonist negative control. Cyclic di-uridine monophosphate (c-di-UMP) is a synthetic cyclic dinucleotide containing a pyrimidine base. Unlike the purine-containing cyclic dinucleotides (c-di-AMP, c-di-GMP and c-di-IMP), c-di-UMP is not predicted to bind strongly to STING [1]. The smaller size of the pyrimidine base is expected to prevent the formation of stacking interactions that are crtitical for proper binding to STING. Indeed, STING-expressing cells, such as THP1-Blue™ ISG cells, do not respond to c-di-UMP, even at high concentrations. Reference: 1. Yin Q. et al., 2012. Cyclic di-GMP sensing via the innate immune signaling protein STING. Mol Cell. 46(6):735-45.
  • Additional Information

    Supplier name InvivoGen
    Product Type Reagents
    Size 1 mg
    Aliases Cyclic di-uridine monophosphate, c-di-UMP sodium salt
    Publications Publication List
    Datasheet URL View Datasheet
    Categories Reagents,PRR ligands
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