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Nigericin, 10 mg

Nigericin, 10 mg

Quick Overview:

Product Code: tlrl-nig
Supplier: InvivoGen

  • Details

    NLRP3 Inflammasome Inducer - Nigericin, sodium salt. Nigericin is a microbial toxin derived from Streptomyces hygroscopicus. Nigericin acts as a potassium ionophore. The release of IL-1β in response to nigericin has been demonstrated to be NALP3-dependent [1]. Similar to ATP, nigericin induces a net decrease in intracellular levels of potassium which is crucial for the activation of caspase-1 [2]. Nigericin requires signaling through pannexin-1 to induce caspase-1 maturation and IL-1β processing and release [3]. References: 1. Mariathasan S. et al., 2006. Cryopyrin activates the inflammasome and ATP. Nature 440;228-32. 2. Locovei S. et al., 2007. Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex. FEBS Lett. 581(3):483-8. 3. Pelegrin P, & Surprenant A., 2007. Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway. J Biol Chem. 282(4):2386-94.
  • Additional Information

    Supplier name InvivoGen
    Product Type Reagents
    Size 10 mg
    Aliases Antibiotic K178, Polyetherin A
    Publications Publication List
    Datasheet URL View Datasheet
    Categories Reagents,PRR ligands,COVID-19 Products
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