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Poly(I:C) (HMW) VacciGrade™, 10 mg

Poly(I:C) (HMW) VacciGrade™, 10 mg

Quick Overview:

Product Code: vac-pic
Supplier: InvivoGen

  • Details

    Poly(I:C) HMW VacciGrade™ is a synthetic analog of double-stranded RNA (dsRNA) and a strong inducer of type I IFNs. It is prepared under strict aseptic conditions, is guaranteed to be sterile and is thoroughly tested to confirm the absence of endotoxins. Poly(I:C) HMW VacciGrade™ is suitable for preclinical studies. Depending on its location in the cell, poly(I:C) can activate innate immunity through distinct PRR pathways: endosomal poly(I:C) activates TLR3, whereas cytosolic poly(I:C) activates RIG-I/MDA-5 and PKR. Triggering the TLR3 pathway induces IL-12 and type I IFNs, whereas stimulation of RIG-I/MDA-5 enhances the production of type I IFNs. Poly(I:C) promotes Th1-dominant immunity through its induction of IL-12 and type I IFNs.
  • Additional Information

    Supplier name InvivoGen
    Product Type In Vivo Reagents
    Size 10 mg,10 mg
    Aliases Polyinosine-polycytidylic acid -TLR3 agonist
    Publications Publication List
    Datasheet URL View Datasheet
    Categories In Vivo Reagents,Vaccine Adjuvants & Reagents
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