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Quick Overview:

Product Code: thp-dasc
Supplier: InvivoGen

  • Details

    To determine if a given signal is an inflammasome inducer. THP1-defASC cells are derived from THP-1 human monocytic cells. THP-1 cells are the most commonly used model cell line for the study of inflammasome activation as they express high levels of NLRP3, ASC and pro-caspase-1. THP1-defASC cells express negligible levels of ASC but express native levels of NLRP3 and pro-caspase-1. These cells are unable to respond to inducers of ASC dependent inflammasomes, such as inducers of the NLRP3 inflammasome. THP1-defASC cells are designed as tools to determine whether a signal activates the inflammasome and in particular the NLRP3 inflammasome. The positive control cell line for inflammasome studies are THP1-Null cells.
  • Additional Information

    Supplier name InvivoGen
    Product Type Cell & Tissue Culture
    Size 3-7 x 10e6 cells
    Publications Publication List
    Datasheet URL View Datasheet
    Categories Cell & Tissue Culture,Cell Lines,COVID-19 Products
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