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Quick Overview:

Product Code: thp-dcasp1
Supplier: InvivoGen

  • Details

    Human monocytes with reduced Caspase-1 activity. THP1-defCASP1 cells are derived from THP-1 human monocytic cells. THP-1 cells are the most commonly used model cell line for the study of inflammasome activation as they express high levels of NLRP3, ASC and pro-caspase-1. THP1-defCASP1 cells are highly deficient for caspase-1 activity (~7 fold reduction). They produce significantly less IL-1β in response to stimuli that activate the inflammasomes, such as ATP, MSU, and chitosan ultrapure (NLRP3 inflammasome) or transfected poly(dA:dT) (AIM2 inflammasome), when compared to the parental cell line THP1-Null. THP1-defCASP1 cells, together with the control cell line THP1-Null, allow to determine if a compound is an inflammasome inducer. The production of IL-1β can be detected using HEK-Blue IL-1β reporter cell line. THP1-defCASP1 cells are resistant to hygromycin B.
  • Additional Information

    Supplier name InvivoGen
    Product Type Cell & Tissue Culture
    Size 3-7 x 10e6 cells
    Publications Publication List
    Datasheet URL View Datasheet
    Categories Cell & Tissue Culture,Cell Lines,COVID-19 Products
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