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Quick Overview:

Product Code: thp-dnlp
Supplier: InvivoGen

  • Details

    Human monocytes with reduced NLRP3 activity. THP1-defNLRP3 cells are derived from THP-1 human monocytic cells. THP-1 cells are the most commonly used model cell line for the study of inflammasome activation as they express high levels of NLRP3, ASC and pro-caspase-1. THP1-defNLRP3 cells have reduced NLRP3 activity but are proficient for ASC and caspase-1 activities. THP1-defNLRP3 cells display significantly weaker responses to inducers of the NLRP3 inflammasome, such as ATP and MSU, when compared to THP1-Null cells. THP1-defNLRP3 cells also show a greatly reduced response to extracellular calcium, a danger signal that activates the NLRP3 inflammasome. However, THP1-defNLRP3 cells may respond to signals that activate other ASC-dependent inflammasomes, such as NLRP1 and NLRC4 inflammasomes. THP1-defNLRP3 cells are designed as tools to study the involvement of NRLP3 in response to a given signal. The positive control cell line for inflammasome studies are THP1-Null cells.
  • Additional Information

    Supplier name InvivoGen
    Product Type Cell & Tissue Culture
    Size 3-7 x 10e6 cells
    Publications Publication List
    Datasheet URL View Datasheet
    Categories Cell & Tissue Culture,Cell Lines,COVID-19 Products
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