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Quick Overview:

Product Code: thp-nlrc4
Supplier: InvivoGen

  • Details

    NLRC4 inflammasome test cell line. THP1-NLRC4 cells are derived from the THP1 human monocytic cell line, which represents the most commonly used model cell line to study inflammasome activation. THP1-NLRC4 cells stably overexpress NLRC4 and naturally express TLR5. Stimulation of these cells with flagellin triggers TLR5 signaling leading to NF-κB activation and the production of pro-IL1β. Once in the cytosol, flagellin induces the formation of the NLRC4 inflammasome resulting in the activation of caspase-1 and the release of IL-1β. Levels of IL-1β secreted into the supernatant of THP-1 cells can be monitored using the HEK-Blue™ KD-TLR5 cell line.
  • Additional Information

    Supplier name InvivoGen
    Product Type Cell & Tissue Culture
    Size 3-7 x 10e6 cells
    Publications Publication List
    Datasheet URL View Datasheet
    Categories Cell & Tissue Culture,Cell Lines,COVID-19 Products
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