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THP1-Null

THP1-Null

Quick Overview:

Product Code: thp-null
Supplier: InvivoGen

  • Details

    Positive control cell line for inflammasome studies. THP1-Null cells are derived from THP-1 human monocytic cells, that represent the most commonly used model cell line for the study of inflammasome activation as they express high levels of NLRP3, ASC and pro-caspase-1. THP1-Null cells produce IL-1β upon stimulation with inflammasome inducers, such as MSU crystals and ATP. As THP1-Null cells are fully efficient for NLRP3 and ASC activities, they are the positive control cell line for THP1-defASC and THP1-defNLRP3, that are deficient in ASC and NLRP3 respectively.
  • Additional Information

    Supplier name InvivoGen
    Product Type Cell & Tissue Culture
    Size 3-7 x 10e6 cells
    Publications Publication List
    Datasheet URL View Datasheet
    Categories Cell & Tissue Culture,Cell Lines,COVID-19 Products
  • Images